Diffuse large b-cell lymphoma is the most common form of non-Hodgkin's lymphoma, which ranks 6th in both men and women when it comes to cancer incidence and mortality (excluding prostate and breast cancer). This can seem like a daunting disease for the medical student or resident to understand, but I try and break it down into manageable pieces here. This video explains the subtypes of DLBCL, including germinal center b-cell type vs activated b-cell type, the basic molecular biology and genetics, including the myc, bcl-2, and bcl-6 genes, and the workup needed to diagnose diffuse large b-cell lymphoma. This video is intended to be at the level of a internal medicine resident. Twitter/X: #lymphoma #cancertherapy #moleculargenetics #hematology #oncology 00:00 Intro 00:39 Epidemiology 01:55 Molecular Biology and Genetics 05:03 Subtypes 16:18 CNS DLBCL 20:23 Workup and Pathology 25:52 Outro References: (14)00032-X#:~:text=BCL6%20mechanism%2Dspecific%20targeting%20kills,transcription%20factor%20targeted%20therapy