Cancer therapies are constantly changing and can be difficult to get a firm grasp of the many options. In this video I explain the primary therapies used to treat diffuse large b-cell lymphoma (DLBCL). We first discuss the NCCN recommend treatment algorithm. Then we go into some of the specific therapies and regimens used, including R-CHOP, O-CHOP, DA-EPOCH-R, Pola-R-CHP, RICE, MATRIX, and CAR-T. This video is intended to be at the level of a internal medicine resident. Twitter/X: #lymphoma #cancertherapy #moleculargenetics #hematology #oncology 00:00 Introduction 00:39 Treatment Flowchart 03:16 Overview of Therapies 04:00 R-CHOP 07:43 O-CHOP 09:13 DA-EPOCH-R 12:13 Pola-R-CHP 14:17 CNS Prophylaxis 16:18 CNS Therapy 17:50 CAR-T Therapy 20:06 Outro References: %201/783/266048/No-Added-Benefit-of-Eight-Versus-Six-Cycles-of %201/1560/79435/Six-Cycles-of-R-CHOP-21-Is-Non-Inferior-to-8 #sec-3 %201/3090/503777/DA-EPOCH-R-for-High-Grade-B-Cell-Lymphoma-Patients %201/7260/505871/CNS-Prophylaxis-in-Diffuse-Large-B-Cell-Lymphoma-A