Non-Hodgkin's lymphoma (NHL) is the most common type of lymphoma and consists of many different subtypes. Before diving into any of these subtypes, familiarize yourself with the basics of non-Hodgkin's. This video explains the initial workup and path to diagnosis of NHL including laboratory testing, imaging, and pathology needed. We also discuss some high yield genetic, disease, and drug associations. Finally, we discuss the Ann Arbor staging system for lymphoma and the various forms of the International Prognostic Index for various subtypes of NHL. This video is intended to be at the level of 4th year medical student and internal medicine resident. Twitter/X: #lymphoma #cancertherapy #hematology #oncology 00:00 Intro 00:42 Subtypes 02:07 Epidemiology 03:10 Infection Associations 04:29 Disease and Drug Associations 05:43 Genetic Associations 06:41 Initial Workup 11:43 Staging 15:00 Prognostication 16:52 Outro References: Harrison's Internal Medicine 21st Edition