Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine’s diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects. Amplify creatine’s muscle- and brain-boosting benefits with science-backed training strategies—download your free guide at CHAPTERS: 00:00:00 Introduction 00:00:56 What makes creatine effective for exercise performance? 00:04:23 The loss of explosive power with aging 00:05:59 How creatine speeds up recovery between sets 00:08:36 Two ways creatine boosts muscle strength 00:10:34 Why creatine might not speed typical weight-training recovery 00:13:01 Anti-catabolic effects 00:13:38 Why do men and women respond differently? 00:15:12 Dietary creatine vs. supplementation 00:15:59 Is creatine supplementation necessary—or optional? 00:17:27 Why plant-based may benefit most 00:18:38 Should creatine dosage change with age? 00:19:23 Loading vs. daily dosing 00:22:20 Why 5 grams might not be enough—other tissues 00:24:11 Can creatine prevent bone loss—even without weight training? 00:24:32 How creatine supports osteoblast activity 00:26:13 Preventing hip fractures with creatine 00:28:55 Creatine vs. bisphosphonates 00:32:43 Why creatine isn’t just for weightlifters 00:35:14 Why stressed brains benefit most 00:37:19 Why brain aging accelerates demand 00:40:16 Why 10g per day might be the optimal dose 00:42:07 Why creatine counteracts sleep deprivation 00:45:16 Before vs. after concussion 00:47:39 Should dosage be adjusted by weight? 00:49:01 Does creatine improve sleep on training days? 00:52:22 Creatine for Alzheimer’s and Parkinson’s—does the science hold up? 00:53:55 Can creatine help with depression and anxiety? 00:57:12 The role of creatine and glutamine in preventing respiratory illness 00:59:28 Why creatine may enhance endothelial health and circulation 01:00:52 Creatine’s role in cardiometabolic health 01:02:33 When does loading actually make sense? 01:03:38 Creatine’s dual role—preserving muscle and enhancing recovery after injury 01:06:33 Is creatine effective without exercise? 01:08:49 Why creatine might improve male fertility 01:10:45 Is it safe for children? 01:14:09 Creatine supplementation during pregnancy 01:15:41 Could creatine boost motor skills in kids? 01:16:21 Creatine monohydrate vs. the rest 01:21:03 How to avoid digestive issues with creatine supplementation 01:23:44 Does timing matter—and should you cycle it? 01:25:20 Should you take creatine every day—or only workout days? 01:26:05 Why caffeine might blunt the effects 01:29:09 Does creatine increase body fat—or is that a myth? 01:29:56 Preventing cramps (the hydration myth) 01:31:21 Understanding the creatinine confusion—why creatine won’t damage your kidneys 01:33:47 Why creatine is linked (wrongly?) to baldness 01:37:10 Debunking myths—sleep, cancer, urination 01:40:27 How creatine affects homocysteine levels 01:43:20 Creatine and protein—the ideal post-workout pair? 01:46:14 How to pick the best creatine supplement 01:48:34 What to know about micronized creatine Darren's response to recent headlines claiming creatine supplements are "worthless": *Darren Candow, PhD* X: Instagram: Publications: *EPISODE LINKS* Show notes & transcript: *PODCAST INFO* Apple Podcasts: Spotify: *SUPPORT MY MISSION* Get access to 120+ episodes of my private podcast ("The Aliquot") when you become a FoundMyFitness Premium Member: #creatine