BLACK FRIDAY SPECIAL (20% off Sentia Spirits) (Use Code GIANT10 for additional 10% discount off your first purchase: Download my FREE EBook 26 Neuroscience Books for 2026 HERE: Professor David Nutt is a neuro­psychopharmacologist, former UK chief drug adviser, and author of Drugs Without the Hot Air, Drink?, Cannabis, and Psychedelics. He built the first evidence-based Drug Harm Scale, ran the world’s first LSD brain-scan, and is now engineering hangover-free “alcohol” with GABA science. Drug policy often punishes the wrong substances. In this rapid-fire tier-list episode, Nutt ranks ten headline drugs—LSD to fentanyl—by real-world harm, exposing how politics, potency and route of use twist our perceptions and our laws. Expect to learn why alcohol and tobacco still out-kill every illegal drug, how MDMA became both a rave staple and a prescription therapy, the science behind ketamine’s antidepressant buzz and its bladder danger, why 2 mg of fentanyl can be fatal, how smoking vs injecting changes heroin risk, what makes high-THC cannabis a new drug entirely, the true neurotoxicity story of cocaine, why psilocybin and LSD aren’t addictive, how Sentia mimics a glass of wine without the damage, and much more… Timestamps: 00:00 Intro 00:55 LSD 09:55 MDMA 24:16 Cocaine 34:21 Psilocybin 37:09 Fentanyl 40:57 Cannabis 43:35 Tobacco 45:00 Alcohol 49:49 Ketamine 51:20 Heroin ... Buy Nutt's Books Drink?: The New Science of Alcohol and Your Health: Psychedelics: The Revolutionary Drugs That Could Change Your Life―A Guide from the Expert: Drugs without the hot air: Making sense of legal and illegal drugs: Cannabis (Seeing Through the Smoke): The New Science of Cannabis and Your Health: Check out the amazing work of Drug Science (Dr David Nutt's Charity) Website - Prof Nutt Twitter (X) - @ProfDavidNutt Drug Science Socials Facebook - @DrugScienceISCD Twitter (x) - @drug_science Instagram - @drugscienceinfo LinkedIn - @drugscience-ltd BlueSky - @ YouTube - @DrugScience More Resources on Drug Safety Medical Cannabis: Medical Psychedelics: Harm Reduction: Academic Research: Follow My Neuroscience Podcast - The Giants Shoulder Spotify - Apple Podcasts - Neuroscience Products I Swear By (Supports the Channel) Manta Sleep Mask: Get the Comfiest Sleep Mask on the Planet (Use Code GIANTSMANTA10 ) [ ]( ): Music Entrainment for Focused Deep Work (30 Day Free Trial: ) ( ): AI Powered Research